Pittman, the team’s leading receiver, is recovering from a quad injury. He caught nine passes for 121 yards and a touchdown in a Week 1 tie against the Houston Texans. Coach Frank Reich had expressed optimism that Pittman would be able to play after he began experiencing pain Wednesday and was held out of practice. The Colts on Friday had already ruled out receiver Alec Pierce and linebacker Shaquille Leonard for this week’s game. With the injuries on offense, receivers Parris Campbell and Ashton Dulin and running back/slot receiver Nyheim Hines could see increased roles against the Jaguars. There could also be a bigger workload for starter Jonathan Taylor, who had 31 carries last week. Indianapolis also promoted receiver Keke Coutee and kicker Chase McLaughlin to the active roster from the practice squad. McLaughlin, who was signed to the practice squad Tuesday along with Lukas Havrisik, will handle kicking duties against the Jaguars on Sunday. McLaughlin, who is in his second stint with the Colts after kicking for Indianapolis for part of the 2019 season, will replace Rodrigo Blankenship, who was fired after missing a game-winning drive against Houston. McLaughlin said he has spent time with 10 different teams in his four years, making 75.5 percent of his attempts. ESPN’s Stephen Holder contributed to this report.